Bone Morphogenetic Proteins (BMPs) are a family of ligands that belong to the Transforming Growth Factor β (TGFβ) superfamily (Ref). They were originally recognized for their ability to induce bone formation (Ref).
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.h3 Expression
BMPs are typically secreted as homomeric dimers.---- test ----
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Table: Binding affinities of BMP family ligands to BMP receptors.
a) BMPs
| BMP2 | BMP3 | BMP3B | BMP4 | BMP5 | BMP6 | BMP8A | BMP8B | BMP9 | BMP10 | BMP11 | BMP14 | BMP15 | |
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Alk2 |
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Alk3 |
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Alk6 |
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BRII |
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ActRII |
| v. weak |
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ActRIIB |
| medium |
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