Seitenhistorie

Virus

Measles Virus 

MeV

Strain/Type

Genus: Morbillivirus

Host tropism

Humans.

Transmission takes place from acutely ill persons who excrete the virus in their nasal and pharyngeal secretions.

This biological agent is host-dependent parasitical.

Route of Transmission

Transmission takes place orally (by ingestion).

Droplet infection.

Transmission generally takes place by droplet infection or contact with nasal or pharyngeal secretions from diseased patients that contain the virus.

Admission over the respiratory tract.

Microbial contaminated aerosols (bioaerosols) are inhalable due to their size and can thus get in the lung.

Admission over the mouth.

A transmission takes place by touching the mouth with dirty hands or gloves or smoking without prior thorough cleaning of the hands (smear infection).

Special hazard exists in the case of contact with infected people and animals or their excretion.

Admission through the skin or the mucous membranes.

Splash in the eyes or mucous membranes of the mouth must be considered as portal of entry.

Zoonosis (transmission between animals and humans): No

Dogs can be experimentally infected, but show no symptoms. 

Characteristics e.g. sensitizing or toxic effects, replication deficiant, not infectious, attenuated, inactivated (upload relevant documents)

Human-pathogenic (causes diseases in humans).

Note V:

Effective vaccine available. The "V" tag has been adopted from Annex III of Directive 2000/54/EC.

Approved as biological safety measure if taken as recipient organism for genetic engineering?

Genetically modified (GenTSV)

Risk group (BioStoffV)

2

Risk assessment

Risk accessment based on TRBA (Technical Rule for Biological Agents) 462 "Classification of viruses into risk groups": https://www.baua.de/DE/Angebote/Rechtstexte-und-Technische-Regeln/Regelwerk/TRBA/TRBA-462.html

Operation instructions (mandatory for RG2 and higher)

https://biostoffe.dguv.de/data?name=830757&lang=en

Occupational health care (according to ArbMedVV)

Mandatory health care:
In the case of tasks specifically involving contact with the biological agent, an health care must be provided by the employer before commencement and then at regular intervals.
In the case of tasks involving incidental contact with the biological agent in research facilities or laboratories where regular activities which involve the possibility of coming into contact with infected or suspected samples, with infected or suspected animals, or objects or materials containing or contaminated with pathogens are carried out, the employer must provide an health care.
An health care must also be provided in the case of the following tasks involving incidental contact :
- In facilities for the medical examination, treatment or care of persons in the case of activities involving regular direct contact with sick or suspected persons.
- In facilities looking after pre-school children in the case of activities with regular, direkt contact with children.
When finishing an activity for which mandatory health care had to be occasioned, the employer must offer optional health care.
An optional health care must also be offered if as a result of the exposure to biological agents
- a serious infectious illness is to be expected and post-exposure prophylatic measures are possible, or
- an infection has resulted.

Vaccination:

Vaccines that have been used millions of times worldwide and whose safety and effectiveness have been proven many times over have been available since 1963. The vaccines are available as single vaccines or as combination vaccines with additional protection against mumps and rubella.

With the entry into force of the "Law for the Protection against Measles and for the Strengthening of Vaccination Prevention" on 01.03.2020, all persons born after 1970 who are cared for in a community institution or work in medical facilities are obliged to prove their immune protection against a measles virus infection.

Storage location of aliquots in the Biolab (just click Bearbeiten in the right corner of the header to add or change information in the table and use the menue in the left header to e.g. add a row)

Background

Cultivation and freezing protocols

Data sheets, inactivation cetificate, further information