Bone Morphogenetic Proteins (BMPs) are a family of ligands that belong to the Transforming Growth Factor β (TGFβ) superfamily.
BMPs are typically secreted as homomeric dimers.
Table: Binding affinities of BMP family ligands to BMP receptors.
a) BMPs
|
BMP2 |
BMP3 |
BMP3B |
BMP4 |
BMP5 |
BMP6 |
BMP7 |
BMP8A |
BMP8B |
BMP9 |
BMP10 |
BMP11 |
BMP15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alk2 |
|
|
|
|
|
|
|
|
|
|
|
|
|
Alk3 |
|
|
|
|
|
|
|
|
|
|
|
|
|
Alk6 |
|
|
|
|
|
|
|
|
|
|
|
|
|
BRII |
|
|
|
|
|
|
|
|
|
|
|
|
|
ActRIIA |
|
weak |
|
|
|
|
|
|
|
|
|
|
|
ActRIIB |
|
solid |
|
|
|
|
|
|
|
|
|
|
|
b) GDFs
|
GDF1 |
GDF2 |
GDF3 |
GDF4 |
GDF5 |
GDF6 |
GDF7 |
GDF8 |
GDF9 |
GDF9B |
GDF10 |
GDF11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alk2 |
|
|
|
|
|
|
|
|
|
|
|
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Alk3 |
|
|
|
|
|
|
|
|
|
|
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Alk6 |
|
|
|
|
|
|
|
|
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|
BRII |
|
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ActRIIA |
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ActRIIB |
|
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Weighing of binding affinities:
n/a, none, very weak (kD > ), weak (kD x1 - x2), medium (kD x2 - x3), solid (kD x3 -x4), strong (kD 1nM - 0.5nM), very strong (kD < 0.5nM)
Further reading:
