Bone Morphogenetic Proteins (BMPs) are a family of ligands that belong to the Transforming Growth Factor β (TGFβ) superfamily.
BMPs are typically secreted as homomeric dimers.
---- test ----
Table: Binding affinities of BMP family ligands to BMP receptors.
a) BMPs
|
BMP3 |
BMP3B |
BMP5 |
BMP6 |
BMP8A |
BMP8B |
BMP9 |
BMP10 |
BMP11 |
BMP14 |
BMP15 |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alk2 |
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Alk3 |
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Alk6 |
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BRII |
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ActRII |
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v. weak |
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ActRIIB |
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medium |
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b) GDFs
|
GDF1 |
GDF2 |
GDF3 |
GDF4 |
GDF5 |
GDF6 |
GDF7 |
GDF8 |
GDF9 |
GDF9B |
GDF10 |
GDF11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alk2 |
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Alk3 |
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Alk6 |
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BRII |
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ActRII |
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ActRIIB |
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Estimation of binding affinities:
n/a, none, very weak (kD > 1µM), weak (kD 1µM - 100nM), medium (kD 99nM - 50nM), solid (kD 49 -10nM), strong (kD 10nM - 0.5nM), very strong (kD < 0.5nM)
Comment: Please correct the given values!
Further reading:
