BMP4

Bone morphogenetic protein 4 (BMP4)

Processing

The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor (Ref).

Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4 (Ref).

Targeting of bone morphogenetic protein growth factor complexes to fibrillin (Ref).

Expression

Developmental stages, tissues, etc.

Knockouts

Types of knockouts, phenotypes, etc.

Further reading:

• BMP2
• BMP4
• BMP7
• GDF5